High-Dose Extended-Release Lansoprazole (Dexlansoprazole) and Amoxicillin Dual Therapy forHelicobacter pyloriInfections
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چکیده
منابع مشابه
A Pilot Randomized Controlled Study of Dexlansoprazole MR-Based Triple Therapy for Helicobacter Pylori Infection
Dexlansoprazole MR is the R-enantiomer of lansoprazole that is delivered by a dual delayed release formulation. It is effective for symptom control of patients with gastroesophageal reflux disease. However, its efficacy in the treatment of Helicobacter pylori infection remains unclear. This pilot, randomized, controlled, head-to-head study was conducted to investigate whether the efficacy of si...
متن کاملHigh-dose esomeprazole and amoxicillin dual therapy for first-line Helicobacter pylori eradication: a proof of concept study
BACKGROUND The prevalence of resistance to clarithromycin and metronidazole has considerably increased, with a corresponding decrease in the eradication rate for Helicobacter pylori (H. pylori) infection. Primary resistance to amoxicillin is extremely low, and esomeprazole was found to exert a noteworthy antimicrobial activity in vitro against H. pylori. A dual therapy with high-dose of esomepr...
متن کاملDexlansoprazole Delayed Release: pharmacotherapy of erosive esophagitis and GeRD
Dexlansoprazole MR is a modified release formulation of the R-enantiomer of lansoprazole, which employs a novel Dual Delayed Release (DDR) technology. Pharmacokinetic studies have shown that the DDR technology provides a two peaks drug release, accuring 1–2 hours and 4–5 hours after dosing, leading to an extended duration of therapeutic plasma drug concentrations compared with conventional dela...
متن کاملAntimicrobial studies of extended release amoxicillin trihydrate dental gels
The aim of this study was to formulate and evaluate the novel amoxicillin trihydrate dental gel containing different hydrophilic polymers such as hydroxy propyl methyl cellulose (HPMC), methyl cellulose (MC), sodium carboxy methyl cellulose (Sod.CMC) and hydroxy propyl cellulose (HPC) in varied concentrations (5, 6, 6 and 9 %) for the treatment of periodontal diseases. Propylene glycol was used...
متن کاملComparator pH study to evaluate the single-dose pharmacodynamics of dual delayed-release dexlansoprazole 60 mg and delayed-release esomeprazole 40 mg
BACKGROUND This paper describes a Phase 1, single-center, randomized, open-label, two-period crossover study which compared the pharmacodynamic effects of single doses of dexlansoprazole modified-release 60 mg and esomeprazole 40 mg on 24-hour intragastric pH in healthy adult subjects. METHODS Forty-four subjects aged 20-54 years were randomized in a 1:1 ratio to two sequence groups defining ...
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ژورنال
عنوان ژورنال: Helicobacter
سال: 2014
ISSN: 1083-4389
DOI: 10.1111/hel.12126